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Pooling Method for Accelerated Testing of COVID-19


Technion and Rambam Health Care Campus scientists present a novel method for testing more than 60 patients simultaneously

 

Researchers at Technion - Israel Institute of Technology and Rambam Health Care Campus have successfully tested a method that will dramatically increase the current COVID-19 testing capacity using existing available resources. This method, known as pooling, enables simultaneous testing of dozens of samples. Its implementation has the potential to greatly accelerate the rate of testing and detection of COVID-19 infected patients in the population. The trial was completed in a matter of days thanks to the support of the Ministry of Health and the close collaboration between Technion and Rambam.


Testing for COVID-19 is currently being conducted in Israel with the focus on people with specific symptoms. The current rate of testing - about 1,200 a day – does not allow for monitoring of asymptomatic carriers in the population, which is vital to curb the epidemic.

 

COVID-19 is diagnosed with PCR testing, which is common for virus monitoring. This test examines the presence of a unique genetic sequence of viruses in a sample taken from the patient. The test takes several hours thus generating a bottleneck in identifying COVID-19 infected people in Israel and around the world. According to Dr. Yuval Gefen, director of the Rambam Clinical Microbiology Laboratory, “Today, we receive approximately 200 COVID-19 test samples a day, and each sample undergoes individual examination. According to the new pooling approach we have currently tested, molecular testing can be performed on a "combined sample," taken from 32 or 64 patients. This way we can significantly accelerate the testing rate. Only in those rare cases, where the joint sample is found to be positive, will we conduct an individual test for each of the specific samples.”

 

According to Professor Roy Kishony, head of the research group in the Faculty of Biology at Technion, “This is not a scientific breakthrough, but a demonstration of the effectivity of using the existing method and even the existing equipment to significantly increase the volume of samples tested per day. This is done by pooling multiple samples in a single test tube. Even when we conducted a joint examination of 64 samples in which only one was a positive carrier, the system identified that there was a positive sample. Although there are some logistical challenges in implementing the method, we expect that it will greatly increase the volume of samples tested per day so that we can identify the asymptomatic carriers. This approach should reduce the chance of infection and flatten the infection curve.” 

 


Director of the Rambam Virology Lab, Dr. Moran Szwarcwort-Cohen estimates that, “implementing pooling in the final stage of the PCR test will make it easier for us to shorten the entire process and significantly increase the test rate.”


President of the Technion Professor Uri Sivan said: "This experiment conducted by Technion and Rambam researchers is complex, and under normal circumstances would take months. This is a remarkable example of the mobilization of an outstanding team in a time of crisis. The initial experiment was completed in less than four days. This achievement emphasizes the importance of the close relationship between Technion and Rambam and between medicine and engineering. Technion researchers have been enlisted in the war against the Coronavirus and this is one of the many activities currently underway at Technion to combat the spread of the disease.”



General Director of Rambam Health Care Campus Prof. Michael Halberthal said, “This collaboration between Technion and Rambam, for the benefit of all humanity, is just one example of many joint projects between the two institutions. These collaborations are designed to harness the multidisciplinary capabilities of Technion researchers for the advancement of medicine.”


The experiment was led at Technion by Dr. Idan Yelin, together with Noga Aharony, Einat Tamar, and Dina Berenbaum in Prof. Kishony's laboratory together with Amir Argoetti from Professor Yael Mandel-Gutfreund's laboratory, both labs are in the Faculty of Biology. Dr. Esti Messer, head of the Technon Biological Safety Dept, was enlisted to help set up the dedicated laboratory and accompanied the entire experiment. Prof. Kishony holds the Marilyn and Henry Taub Chair in Life Sciences. The Rambam Health Care Campus team was led by Dr. Yuval Gefen and Dr. Moran Szwarcwort-Cohen, and Prof. Michael Halberthal, Rambam General Director and CEO.

Photos

L to r: Prof. Roy Kishony, Einat Tamar, Amir Argoetti, Noga Aharony, and Dr. Idan Yelin

 Dr. Yuval Gefen and Dr. Moran Szwarcwort-Cohen

 More pics at Facebook Israel Diplo

Credit: Technion Spokesperson's Office and Rambam Spokesperson's Office

 

 

 

 

 On March 17, 1992 , At 14.45hs  a powerful bomb shattered the building of the Israel Embassy in Buenos Aires, taking the lives of 29 people. Hezbollah, calling itself a "party of God", claimed responsibility for the attack.

Bombing of the Israel Embassy in Buenos Aires, 1992


At 14.45 on March 17, 1992 a powerful bomb shattered the building of the Israel Embassy in Buenos Aires, taking the lives of 29 people, among them three Israeli embassy personnel, six local embassy employees, and scores of innocent Argentineans, including elderly residents of a nearby nursing home, and schoolchildren on a passing bus.

 In one moment, the embassy and the nearby church were literally wiped off the map. Hezbollah, calling itself a "party of God", claimed responsibility for the attack.

 The Argentine Supreme Court ordered an expert investigation of the attack which was carried out by the head of the national police bomb disposal and explosives unit. The result was conclusive: "The explosion took place outside the building when a car bomb struck the embassy building." Nonetheless, in 1996 the Argentine Supreme Court issued a statement saying it was impossible to determine who was responsible for this act of terror.

 In May 1999, following a formal investigation, the Argentinian Supreme Court accused Hezbollah of the attack and issued an arrest warrant for Imad Mughnieh, commander of Hezbollah military-terrorist wing. An investigation carried out by Israel, whose findings were made public in 2003, showed that the highest levels of the Iranian regime were aware of Hezbollah's intention to carry out the attack and had in fact authorized Hezbollah to carry it out.

 The 2006 report of the findings of the special team which investigated the terrorist attack which destroyed the Jewish Community Center building (AMIA) in Buenos Aires (18 July 1994) states that according to expert testimony, "the modus operandi of the attack was identical to the method employed two years previously in the attack on the Israeli embassy in Buenos Aires (an attack that the Argentinean Supreme Court found was the work of Islamic Jihad in its capacity as the military wing of Hezbollah)."

To date, no one has been brought to justice for these attacks. Israel remains convinced of Iranian responsibility for the bombing of the embassy in 1992 and of the Jewish community center AMIA.

On March 17, 2000, a memorial was inaugurated on the site of the former embassy

A marble monument, a replica of the column of the original embassy building, stands today in the Israeli Embassy in Buenos Aires, in memory of those who died who died on that fateful day in 1992, bearing the verse of the prophet Amos: "I will raise up its ruins and rebuild it as in the days of old."

 

Youtube  Remembering the Terrorist Bombing of Israel's Embassy in Buenos Aires   https://youtu.be/ldRRpLCqOpc

Credit :Israel's Foreign Affairs Ministry

 Foto :Israel's Foreign Affairs Ministry

 

 

 

 

 

 
 
A unique monument dedicated to hundreds of years of history of Jewish and Lithuanian communities was revealed in Jurbarkas, a small town in Lithuania, on Friday. Synagogue Square Memorial eternalizes friendship, tragedy and hope.
 
‘The monument is dedicated to many generations of the Jewish people living in this town and the tragic end of this community. Also, this monument is dedicated to those who saved Jews, and thus this memorial is tightly connected to the Litvak history as a whole. It is the first memorial of such kind. I am happy that we have completed the memorial, with the help of so many good-willed people’, says David Zundelovich, world-acclaimed sculptor and the author of the monument.
 
Jurbarkas was a home to a large Jewish community, with thriving businesses, schools, beautiful synagogue. World War II shattered the fate of Jewish people and Soviet occupation tried to erase history from people’s minds. There are no Jewish people living in Jurbarkas these days. 
 
 
The mayor of Jurbarkas, Skirmantas Mockevičius, asked H.E. Mr. Amir Maimon, the Ambassador of the State of Israel to the Republic of Lithuania to contact Israeli sculptor David Zundelovich and his creative group CAN (New Artists Collegium) with a request to design and create the future memorial. With the help of Israeli embassy in Lithuania, the creative team was established and completed the project with the help of people all over the world.
 
David, Greg and Anna Zundelovich with the creative team of CAN decided to depict history creating a unique project to commemorate the wooden synagogue, names and professions of Jewish people and Lithuanians who had courage to save their Jewish neighbors during World War II.
 
The project which has no analogues in the world united descendants of Jurbarkas Jewish community from Israel, USA, South Afrika, United Kingdom, Russia and Canada, along with philanthropists from Lithuania, Germany and Israel, with the help of Good Will Foundation. It took three years to complete the project.
 
‘This project showcases a new era in Lithuania. Where the people of a country that is highly associated with the Holocaust to every Jew stand strong together, stating "We shall not forget". Where Lithuanians no longer regard their Jewish neighbors as foreigners, but as a part of their own national identity’, said David Zundelovich.
 
A better definition of this monument is a sculptural space rather than a statue in a square, since the impact of this memorial was set to change the town's landscape. The monument consists of many symbols that demonstrate the historical connection of the Jewish community and the town.
 
The general layout is based on the image of the river Nemunas (Neman). The River of Memory, near which the town stands. The stone "river waves" that form the monument are covered with almost 2,000 surnames of all Jewish families that lived in Jurbarkas throughout the ages. 
 ​
The central axis that divides the whole square is oriented towards Jerusalem, the most obvious common principal to both Jews and Christians. The granite axis carries the inscription "If I forget thee, o Jerusalem" and towards its end the names of the local Righteous Among the Nations appear. 
 
Photos courtesy of Lithuania Embassy
 
 
 

.

.At the invitation of the President of the State of Israel, 46 royals, presidents, prime ministers and parliamentary leaders from Europe, North America and Australia, will attend the Fifth World Holocaust Forum, entitled “Remembering the Holocaust, Fighting Antisemitism.” 

The World Holocaust Forum organized by the World Holocaust Forum Foundation in cooperation with Yad Vashem, the World Holocaust Remembrance Center, will take place on 23 January 2020 at the Warsaw Ghetto Square in Yad Vashem, Jerusalem. The Forum marking the 75th anniversary of the liberation of Auschwitz and International Holocaust Remembrance Day, will begin at 13:30.

The event program will include addresses from a number of world leaders: President of the State of Israel H.E. Mr. Reuven "Ruvi" Rivlin, Prime Minister of the State of Israel H.E. Mr. Benjamin Netanyahu, President of France H.E. Mr. Emmanuel Macron, The Prince of Wales, HRH Prince Charles, President of Russia H.E. Mr. Vladimir Putin, as well as a senior leader from the United States of America and the President of Germany H.E. Mr. Frank-Walter Steinmeier. Holocaust survivor and Chairman of the Yad Vashem Council Rabbi Israel Meir Lau as well as Forum organizers – President of the World Holocaust Forum Foundation Dr. Moshe Kantor and Yad Vashem Chairman Avner Shalev – will also speak at the event. Interspersed throughout the proceedings there will be several short video clips and musical interludes performed by an international orchestra conducted by world renowned conductor Vladimir Spivakov accompanied by an international choir.

The event will conclude with a memorial ceremony. Holocaust survivors Rose Moskowitz, from the United States, and Colette Avital, Chairperson of the Central Organization of Holocaust Survivors in Israel will light a memorial torch, after which, heads of delegations will commemorate victims of the Holocaust by laying wreaths at the base of the Warsaw Ghetto Uprising Monument in Warsaw Ghetto Square at Yad Vashem. Cantor Shai Abramson will recite the El Maleh Rahamim memorial prayer, followed by Holocaust survivor Naftali Deutsch who will say Kaddish, the mourner's prayer. The ceremony will conclude with Israel's national anthem, Hatikvah.

The World Holocaust Forum will be broadcast live via satellite feed worldwide and via Yad Vashem's website and Facebook page. The broadcast will be translated simultaneously to six languages – EnglishHebrewFrenchGermanRussian and Spanish.

 

Confirmed Leaders of Nations and Heads of Delegations at the Fifth World Holocaust Forum
(As of 15 January 2020)

President of Albania H.E. Mr. Ilir Meta
President of Armenia H.E. Mr. Armen Sarkissian
Governor-General of Australia The Honourable David Hurley AC DSC (Retd)
Federal President of Austria H.E. Mr. Alexander Van der Bellen
Chairman of the House of Representatives of Belarus H.E. Mr. Vladimir Andreichenko
King of Belgium His Majesty King Phillipe
Chairman of Presidency of Bosnia and Herzegovina H.E. Mr. Željko Komšić
President of Bulgaria H.E. Mr. Rumen Radev
Governor-General of Canada the Right Honourable Ms. Julie Payette
President of Croatia H.E. Ms. Kolinda Grabar-Kitarović
President of Cyprus H.E. Mr. Nicos Anastasiades
Prime Minister of the Czech Republic H.E. Mr. Andrej Babiš
Prime Minister of Denmark H.E. Ms. Mette Frederiksen
President of European Council H.E. Mr. Charles Michel
President of the European Commission H.E. Ms. Ursula von der Leyen
President of the European Parliament H.E. Mr. David Sassoli
President of Finland H.E. Mr. Sauli Niinistö
President of France H.E. Mr. Emmanuel Macron
President of Georgia H.E. Ms. Salome Zourabichvili
President of Germany H.E. Mr. Frank-Walter Steinmeier
President of the Hellenic Republic H.E. Mr. Prokopios Pavlopoulos
Representative of the Holy See His Eminence Cardinal Kurt Koch
President of Hungary H.E. Mr. János Áder
President of Iceland H.E. Mr. Guðni Thorlacius Jóhannesson
President of Italy H.E. Mr. Sergio Mattarella
Speaker of the Saeima of Latvia H.E. Ms. Ināra Mūrniece
President of Lithuania H.E. Mr. Gitanas Nauseda
Grand Duke of Luxembourg HRH Henri
President of Moldova H.E. Mr. Igor Dodon
Minister of State of Monaco H.E. Mr. Serge Telle
President of Montenegro H.E. Mr. Milo Đjukanović
King of the Netherlands His Royal Majesty Willem-Alexander
President of North Macedonia H.E. Prof. Dr. Stevo Pendarovski
Crown Prince of Norway HRH Crown Prince Haakon
President of Portugal H.E. Prof. Marcelo Rebelo de Sousa
President of Romania H.E. Mr. Klaus Iohannis
President of the Russian Federation H.E. Mr. Vladimir Putin
President of Serbia H.E. Mr. Aleksandar Vučić
President of Slovakia H.E. Ms. Zuzana Čaputová
President of Slovenia H.E. Mr. Borut Pahor
King of Spain His Majesty King Felipe VI
Prime Minister of Sweden H.E. Mr. Stefan Löfven
President of Ukraine H.E. Mr. Volodymyr Zelenskyy
The Prince of Wales HRH Prince Charles, United Kingdom
Vice President of the United States of America H.E. Mr. Michael R. Pence*
Speaker of the House of Representatives of the United States of America Congresswoman Nancy Pelosi*
*Awaiting official confirmation

About the Fifth World Holocaust Forum   23 January 2020

Heads of State from Europe, North America and Australia are converging at Yad Vashem, the World Holocaust Remembrance Center, for the Fifth World Holocaust Forum, taking place on 23 January 2020. The event, entitled “Remembering the Holocaust: Fighting Antisemitism,” is being organized by the World Holocaust Forum Foundation, headed by Dr. Moshe Kantor, in cooperation with Yad Vashem, under the auspices of the President of the State of Israel, H.E. Mr. Reuven "Ruvi" Rivlin.

As the world marks the 75th anniversary of the liberation of Auschwitz, the message is clear – antisemitism has no place in our global society.

This historic event takes place against the background of the rise in hateful and violent expressions of antisemitism, especially in Europe. Given this alarming situation, efforts to educate about the dangers of antisemitism, racism and xenophobia and foster Holocaust commemoration, education and research have made this event more crucial and relevant than ever.

The Holocaust, aimed at the total annihilation of all Jews everywhere, and the eradication of their culture and history, was fueled by extreme racist antisemitism. In the aftermath of the Second World War, the international community enacted universal principles and instituted international organizations with the express purpose of averting future crimes against humanity. The ways in which antisemitism has persisted since the war and proliferated over recent years need to be identified, studied and understood. World leaders must be alert to antisemitism's current manifestations, and remain resolute in combatting it where it appears. It is the responsibility of all humanity, and especially the leaders that are gathering at Yad Vashem, to work to fight antisemitism, racism and xenophobia.

Yad Vashem works tirelessly to increase the knowledge and awareness of the history of the Holocaust, not only to ensure that its meanings continue to be relevant 75 years after the end of WWII, but also as a lighthouse warning against the alarming racism that is on the rise around the world today.

 

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Throughout their long history, the yearning to return to the Land of Israel has been the focus of Jewish life. Independence Day is a celebration of the renewal of the Jewish state in the land where the Jewish people began to develop its distinctive religion and culture some 4,000 years ago. ​​​​

Israel Independence Day is celebrated annually on the anniversary of the establishment of the State of Israel, according to the Hebrew calendar, on 5 Iyar.

 The day preceding this celebration is devoted to the memory of those who gave their lives for the achievement of the country's independence and its continued existence.

 This proximity is intended to remind people of the heavy price paid for independence. On this day the entire nation remembers its debt and expresses eternal gratitude to its sons and daughters who gave their lives for the achievement of the country's independence and its continued existence.

  On May 14, 1948, the day the British Mandate expired, the new Jewish state - the State of Israel - was formally established in parts of what was known as the British Mandate for Palestine. With the establishment of the State of Israel in 1948, Jewish independence was restored after 2,000 years.

  Independence Day is a celebration of the renewal of the Jewish state in the Land of Israel, the birthplace of the Jewish people. In this land, the Jewish people began to develop its distinctive religion and culture some 4,000 years ago, and here it has preserved an unbroken physical presence, for centuries as a sovereign state, at other times under foreign domination. Throughout their long history, the yearning to return to the land has been the focus of Jewish life. Theodor Herzl, the leader and founder of the Zionist movement, increased international recognition for the need of a Jewish state.

  Since its establishment, Israel continues to be a homeland to the thousands who make their way to Israel annually. It is home to some of the holiest religious sites of the three major religions, all which enjoy the democratic rights delineated in the Declaration of the Establishment of the State of Israel.​

 

 Independence Day

  ​Israel's 71st Independence Day celebrations will commence on Wednesday evening, May 8, immediately upon the conclusion of Memorial Day for the fallen soldiers and victims of terrorism, when the state flag is raised to full mast at a national ceremony on Mount Herzl, at which 12 torches are lit.

  Independence Day is filled with festivities and celebrations including picnics, barbecues, family gatherings, and nature trips. Balconies, car windows, storefronts and more are liberally decorated with Israeli flags.​

 

Population of Israel

  ​On the eve of Independence Day 2019, the Central Bureau of Statistics announced that the population of Israel at the end of 2018 numbers 8,970,000 - more than ten times the population at the establishment of the state in 1948 (806,000). Jews and others today constitute 79.1% of the population, and Arabs 20.9%. About 75% of the Jewish population is comprised today of native-born Israelis, and more than half are at least second-generation Israelis.

 

 Since the establishment of the state, over 3.2 million immigrants arrived in Israel. As a result, the allocation of Jews in Israel as a percentage of the total Jewish population in the world grew from 6% on the country’s first anniversary to 44% on the eve of the 71st.

In 1948, only Tel Aviv-Jaffa had more than 100,000 residents. Today there are 14 cities in Israel with a population of over 100,000, and 6 others with over 200,000 residents: Jerusalem, Tel Aviv-Jaffa, Haifa, Rishon Lezion, Ashdod and Petah Tikva.

Happy Independence Day!